Education: Ph.D., Georgia State University, Center for Behavioral Neuroscience (2002)
Postdoctoral Training: The Rockefeller University
Emory University School of Medicine
Graduate Areas: Experimental - Behavioral Neuroscience
Specialty: Behavioral Neuroscience/Molecular Biology/Neurophysiology
The Jasnow lab focuses on discovering how environmental experience alters emotional learning, as well as the molecular and cellular mechanisms of fear learning. PTSD and other fear-related disorders are thought to result from an interaction of genetic and environmental factors that enhance the likelihood of a pathological stress response and fear memory following severe trauma. Thus, if we can understand how genetic factors and environmental experience interact to alter basic brain function and ultimately emotional behavior, we can understand how these psychiatric disorders arise and develop potential therapeutic interventions. We use virus-mediated genetic manipulation and transgenic mouse models to discover the basic underlying brain mechanisms regulating prolonged physiological and behavioral responses to traumatic experience.
Lab Site: Behavioral Neuroscience Laboratory
Martin EI, Ressler KJ, Jasnow AM, Dabrowska J, Hazra R, Rainnie DG, Nemeroff CB, Owens MJ. A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biol Psychiatry. 2010 Jun 15;67(12):1212-6. Epub 2010 Mar 29. PubMed PMID: 20303068.
Jasnow AM, Rainnie DG, Maguschak KA, Chhatwal JP, Ressler KJ. Construction of cell-type specific promoter lentiviruses for optically guiding electrophysiological recordings and for targeted gene delivery. Methods Mol Biol.2009;515:199-213. PubMed PMID: 19378132.
Jasnow AM, Ressler KJ, Hammack SE, Chhatwal JP, Rainnie DG. Distinct subtypes of cholecystokinin (CCK)-containing interneurons of the basolateral amygdala identified using a CCK promoter-specific lentivirus. J Neurophysiol. 2009 Mar;101(3):1494-506. Epub 2009 Jan 21. PubMed PMID: 19164102; PubMed Central PMCID: PMC2666417.
Jasnow AM, Mong JA, Romeo RD, Pfaff DW. Estrogenic regulation of gene and protein expression within the amygdala of female mice. Endocrine. 2007 Dec;32(3):271-9. Epub 2008 Feb 5. PubMed PMID: 18247161.
Romeo RD, Karatsoreos IN, Jasnow AM, McEwen BS. Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus. Neuroendocrinology. 2007;85(4):199-206. Epub 2007 May 15. PubMed PMID: 17505125.
Jasnow AM, Shi C, Israel JE, Davis M, Huhman KL. Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala. Behav Neurosci. 2005 Aug;119(4):1125-30. PubMed PMID: 16187840.
Jasnow AM, Schulkin J, Pfaff DW. Estrogen facilitates fear conditioning and increases corticotropin-releasing hormone mRNA expression in the central amygdala in female mice. Horm Behav. 2006 Feb;49(2):197-205. Epub 2005 Aug 3. PubMed PMID: 16083887.
Jasnow AM, Davis M, Huhman KL. Involvement of central amygdalar and bed nucleus of the stria terminalis corticotropin-releasing factor in behavioral responses to social defeat. Behav Neurosci. 2004 Oct;118(5):1052-61. PubMed PMID: 15506887.
Jasnow AM, Cooper MA, Huhman KL. N-methyl-D-aspartate receptors in the amygdala are necessary for the acquisition and expression of conditioned defeat. Neuroscience. 2004;123(3):625-34. PubMed PMID: 14706775.
Jasnow AM, Huhman KL. Activation of GABA(A) receptors in the amygdala blocks the acquisition and expression of conditioned defeat in Syrian hamsters. Brain Res. 2001 Nov 30;920(1-2):142-50. PubMed PMID: 11716820.