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Profile Detail

Christopher Malcuit

Assistant Professor
In indications such as traumatic injury or muscular dystrophy, damaged and atrophic muscle is replaced - not with functional muscle tissue - but rather a fibrous scar.  Surmounting evidence over the past decade has underscored the notion that chemical and mechanical properties of the cellular substratum play crucial roles in predicting stem cell fate through mechanotransduction paradigms.  The overall focus of my research is to study the mechanisms by which discrete components and properties of the extracellular matrix regulate stem cell migration, proliferation, and fate switching in diseased and damaged tissues of the musculoskeletal system.
  Our laboratory employs the use of genetic models and tissue engineered skeletal muscle constructs to study how: 1) Aging and fibrotic muscle tissue negatively regulate the proliferative phase and migratory capacity of skeletal myoblasts through mechanosensory-based mechanisms and 2) The uncoupling of actin microfilaments to extracellular adhesion complexes in dystrophic muscle induces spatial and functional dysregulation of calcium homeostasis, thereby precluding proper self-renewal and tissue regeneration.
Additionally, through collaborations with nearby institutions such as NEOMED and the Cleveland Clinic’s Lerner Research Institute, we are working to characterize immunomodulatory elements involved in skeletal muscle regeneration, as well as to develop robust systems to identify, preserve, and isolate therapeutically relevant cells for the treatment of various clinical indications of musculoskeletal disease.

Graduate Student Research



Prospective graduate students may apply to M.S. or Ph.D. programs in either the Department of Biological Sciences or through the School of Biomedical Sciences.

Undergraduate Student Research



Our laboratory typically accepts several undergraduate researchers per semester to conduct Individual Investigations (1-3 credits).  Interested Kent State University undergraduates should contact Dr. Malcuit for an appointment to discuss research and career goals.
Scholarly, Creative & Professional Activities
Jez M, Ambady S, Olga Kashpur O, Grella A,  Malcuit C, Vilner L, Rozman P, and Dominko T. Expression and differentiation between OCT4A and its pseudogenes in human ESCs and differentiated adult somatic cells.  PLOS ONE. 2014. (In Press). Stanton MM, Rankenberg JM, Park BW, McGimpsey WG, Malcuit C, and Lambert CR. Cell behavior on surface modified polydimethylsiloxane.  Macromolecular Biosciences 2014 (In Press). Sugino IK, Sun Q, Wang J, Nunes CF, Cheewatrakoolpong N, Rapista A, Johnson AC, Malcuit C, Klimanskaya I, Lanza R, et al. Comparison of FRPE and human embryonic stem cell-derived RPE behavior on aged human Bruch's membrane. Investigative ophthalmology & visual science. 2011;52(8):4979-97. Page RL, Malcuit C, Vilner L, Vojtic I, Shaw S, Hedblom E, Hu J, Pins GD, Rolle MW, and Dominko T. Restoration of skeletal muscle defects with adult human cells delivered on fibrin microthreads. Tissue engineering Part A. 2011;17(21-22):2629-40. Lee B, Yoon SY, Malcuit C, Parys JB, and Fissore RA. Inositol 1,4,5-trisphosphate receptor 1 degradation in mouse eggs and impact on [Ca2+]i oscillations. Journal of cellular physiology. 2010;222(1):238-47. Cooney MA, Malcuit C, Cheon B, Holland MK, Fissore RA, and D'Cruz NT. Species-specific differences in the activity and nuclear localization of murine and bovine phospholipase C zeta 1. Biology of reproduction. 2010;83(1):92-101. Ambady S, Malcuit C, Kashpur O, Kole D, Holmes WF, Hedblom E, Page RL, and Dominko T. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. The International journal of developmental biology. 2010;54(11-12):1743-54. Malcuit C, Trask MC, Santiago L, Beaudoin E, Tremblay KD, and Mager J. Identification of novel oocyte and granulosa cell markers. Gene expression patterns : GEP. 2009;9(6):404-10. Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, Lanza R, and Lund R. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem cells. 2009;27(9):2126-35.
Research Areas
  • Stem Cell Biology
  • Skeletal Muscle Regeneration
  • Tissue Engineering
Christopher Malcuit
OFFICE
Department of Biological Sciences
Cunningham Hall
OFFICE HOURS
M/TR: 10am-12pm
CONTACT INFO
Phone: 330-672-3428
Fax: 330-672-4818
cmalcuit@kent.edu
COURSES TEACHING
Spring 2014
  • BSCI 40099 - 007 Senior Honors Thesis
  • BSCI 40195 - 021 St : Advanced Stem Cell Bio
  • BSCI 40196 - 010 Individual Investigation
  • BSCI 40600 - 022 Writing In Biological Sciences
  • BSCI 50195 - 021 St : Advanced Stem Cell Bio
  • BMS 60198 - 032 Research
  • BSCI 70195 - 021 St : Advanced Stem Cell Bio
  • BMS 70295 - 001 Cell - Biomaterials Interactions
Summer 2014
  • BMS 60198 - 007 Research
Fall 2014
  • BSCI 30140 - 001 Cell Biology
  • BSCI 40099 - 002 Senior Honors Thesis
  • BSCI 40600 - 020 Writing In Biological Sciences