Our laboratory employs the use of genetic models and tissue engineered skeletal muscle constructs to study how: 1) Aging and fibrotic muscle tissue negatively regulate the proliferative phase and migratory capacity of skeletal myoblasts through mechanosensory-based mechanisms and 2) The uncoupling of actin microfilaments to extracellular adhesion complexes in dystrophic muscle induces spatial and functional dysregulation of calcium homeostasis, thereby precluding proper self-renewal and tissue regeneration.
Additionally, through collaborations with nearby institutions such as NEOMED and the Cleveland Clinic’s Lerner Research Institute, we are working to characterize immunomodulatory elements involved in skeletal muscle regeneration, as well as to develop robust systems to identify, preserve, and isolate therapeutically relevant cells for the treatment of various clinical indications of musculoskeletal disease.
Graduate Student Research
Prospective graduate students may apply to M.S. or Ph.D. programs in either the Department of Biological Sciences or through the School of Biomedical Sciences.
Undergraduate Student Research
Our laboratory typically accepts several undergraduate researchers per semester to conduct Individual Investigations (1-3 credits). Interested Kent State University undergraduates should contact Dr. Malcuit for an appointment to discuss research and career goals.
Scholarly, Creative & Professional Activities
- Stem Cell Biology
- Skeletal Muscle Regeneration
- Tissue Engineering
OFFICEDepartment of Biological Sciences
OFFICE HOURSM/TR: 10am-12pm
CONTACT INFOPhone: 330-672-3428
COURSES TEACHINGSpring 2014
- BSCI 40099 - 007 Senior Honors Thesis
- BSCI 40195 - 021 St : Advanced Stem Cell Bio
- BSCI 40196 - 010 Individual Investigation
- BSCI 40600 - 022 Writing In Biological Sciences
- BSCI 50195 - 021 St : Advanced Stem Cell Bio
- BMS 60198 - 032 Research
- BSCI 70195 - 021 St : Advanced Stem Cell Bio
- BMS 70295 - 001 Cell - Biomaterials Interactions
- BSCI 30140 - 001 Cell Biology
- BSCI 40600 - 020 Writing In Biological Sciences