Robert V. Dorman
- Ph.D., Ohio State University
- Biological Structure and Function
Dr. Dorman's research deals with the role of neuronal membranes in chemical transmission processes, and the effects of cerebral ischemia on membrane functions. He investigates effects of unesterified arachidonic acid on the release of the excitatory amino acid neurotransmitter glutamate. The release and metabolism of arachidonic acid to eicosanoids is examined in mossy fiber nerve endings isolated from the hippocampus. These nerve terminals have been implicated in learning and memory processes; they appear to be stimulated by arachidonic acid and modulated by certain eicosanoids. Although these investigations are related to the understanding of normal synaptic transmission mechanism, they also appear to be involved in the cerebral damage associated with ischemic trauma. Cerebral ischemia stimulates uncontrolled accumulation of free arachidonic acid and massive release of excitatory amino acids. The excitatory transmitters are may play a central role in neuron death and, therefore, in stroke-induced brain damage.
Immunoflourescent localization of cytosolic phospholipase A2 (cPLA2)
in vascular smooth muscle cells cultured from rat aorta.
|Perinuclear localization of cPLA2 in untreated cells.||Nuclear localization of cPLA2 following 7 mm exposure to Angiotensin II.|
Scholarly, Creative & Professional Activities
Freeman, E.J., Terrian, D.M. and Dorman, R.V. 1990. Presynaptic facilitation of glutamate release from isolated hippocampal mossy fiber nerve endings by arachidonic acid. Neurochemical Research 15: 743-750.
Hamm, T.F.R. and Dorman, R.V. 1990. Arachidonic acid metabolism in gerbil cerebra: effects of ischemia and pentobarbital. Journal of Neuroscience Research 26: 488-494.
Freeman, E.J., Damron, D.S., Terrian, D.M. and Dorman, R.V. 1991. 12-Lipoxygenase products attenuate the glutamate release and Ca2+ accumulation evoked by depolarization of hippocampal mossy fiber nerve endings. Journal of Neurochemistry 56: 1079- 1082.
Zhang, L., Ruehr, M.L. and Dorman, R.V. (1996). Arachidonic acid and oleoylacetylglycerol induce a synergistic facilitation of Ca2+-dependent glutamate release from hippocampal mossy fiber nerve endings. J Neumchem. 66: 177-185.
Ruehr, M.L., Zhang, L. and Dorman, R.V. (1997) Lipid-dependent modulation of Ca2+ availability in isolated mossy fiber nerve endings. Neurochem. Res. 22:1215-1222.
Freeman, E.J., Ruehr, M.L. and Dorman, R.V. (1998) ANG Il-induced translocation of cytosolic phospholipase A2 to the nucleus in vascular smooth muscle cells. Amer. J. Physiol. Cell Physiol. 274:C282-C288.
- Membrane biochemistry related to mechanisms of neurotransmitter release and stroke-induced brain damage
OFFICEDepartment of Biological Sciences
School of Biomedical Sciences
112 Cunningham Hall
CONTACT INFOPhone: 330-672-2263
COURSES TEACHINGSummer 2013
- BMS 60198 - 025 Research
- BSCI 10001 - 004 Human Biology