1996: M.S. Medical Biology. Department of Biology, Free University of Amsterdam, The Netherlands.
2003: Ph.D. Neurobiology. Netherlands Institute for Neuroscience and Department of Medicine, University of Amsterdam, The Netherlands.
Scholarly, Creative & Professional Activities
In my laboratory, we study how fibroblast growth factors to regulate the morphogenesis of the fetal brain, which ultimately impacts brain function. Indeed, abnormal organization of the brain due to embryonic defects in fibroblast growth factor signaling result in dramatic pathophysiological consequences in cognition and autonomic functions.
In our studies, we showed that a slight downregulation of fibroblast growth factor 8 expression causes cortical hypotrophy, agenesis of the corpus callosum, reduced proliferation, and the elimination of entire neuronal populations that are critical for normal body function in transgenic mice. For example, we found that the knockdown of fibroblast growth factor 8 expression in mice eliminates gonadotropin-releasing hormone neurons resulting in the absence of pubertal onset and infertility. Based on these experimentally-derived data we have been able to postulate how fibroblast growth factor 8 mutations found Kallmann syndrome patients causes the hypogonadotropic/hypogonadism and infertility associated with this neurological disorder.
Recently, we have initiated studies to examine how ethanol causes transgenerational defects in neocortical-related brain structures. The health consequences of ethanol consumption are been well-documented, and are reflected by the reported enormous health care-related costs. The goal of this research focus is to better understand how parental ethanol consumption during adolescence affects the brain development of their future offspring, particularly by acting on the fetal fibroblast growth factor signaling by way of epigenetically modifying the regulatory sequences of this gene family.
These studies requires my laboratory to be well-versed in a multidisciplinary and collaborative research approaches, that include behavioral analyses, cell/molecular techniques and collaborating with other labs at or outside of Kent State University.
PhD students can enter the lab through either the Department of Biological Sciences or the School of Biomedical Sciences.
Kent State undergraduates who are interested in doing research should send an e-mail to Prof. Chung with the following information:
Transcript and/or description of courses taken (GPA),
Description of goals after Bachelors degree,
Description of previous research experience, if any
A central mission of the lab is to get undergraduates involved in research. Successful applicants should expect to work in the lab for approximately 1-2 years. Goals include but are not limited to learning research techniques, presentation of research and publication in peer-reviewed journals.
Stevenson EL, Corella KM, Chung WCJ (2013) Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development. Front Endocrinol. 4: 89.
Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung WCJ, et al (2013) Genetic screening of the FGF8 synexpression group identifies rare sequence variants in FGF17, IL17RD, DUSP6, SPRY4 and FLRT3 in patients with Congenital Hypogonadotropic Hypogonadism. American Journal of Human Genetics. 92: 725.
Rao YS, Mott NM, Wang Y, Chung WCJ, Pak TR (2013) A subset of miRNAs are differentially regulated by estrogen in the aging brain. Endocrinology. 154: 2795.
Chung WCJ, Auger AP (2013). Gender differences neurodevelopment and epigenetics. Pflugers Archiv. 465: 573.
Tsai TS, Brooks LR, Rochester JR, Kavanaugh SI, Chung WCJ (2011) Fibroblast growth factor signaling in the developing neuroendocrine hypothalamus. Frontiers of Neuroendocrinology.32: 95.
Chung WCJ, Matthews TA, Tata BK, Tsai PS (2010) Compound deficiencies in multiple FGF signaling components differentially impact the murine GnRH system. J Neuroendocrinology. 22: 944.
Chung WCJ, Moyle SS, Tsai PS (2008) Fibroblast growth factor 8 signaling through FGF receptor 1 is required for gonadotropin-releasing hormone neuronal development in mice. Endocrinology. 149: 4997.
Falardeau J, Chung WCJ, Beekeen A, Plummer L, Sidis Y, Raivio T, Dwyer A, Na S, Hall J, Huot C, Alois N, Quinton R, Cole LW, Hughes V, Mohammadi M, Tsai PS, Pitteloud N (2008). Decreased FGF8 signaling causes GnRH deficiency in human and mice. J Clin Invest. 118: 2822.
Chung WCJ, Pak TR, Suzuki S, Pouliot WA, Andersen ME, Handa RJ (2007). Detection and localization of an estrogen receptor beta splice variant protein (ERbeta2) in the adult female rat forebrain and midbrain regions. J Comp Neurol. 20: 249.
Pak TR, Chung WCJ, Hinds LR, Handa RJ (2007) Estrogen receptor-beta mediates DHT-induced stimulation of the arginine vasopressin promoter in neuronal cells. Endocrinology. 148:3371.
Pak TR, Chung WCJ, Roberts JL, Handa RJ (2006) Ligand-independent effects of estrogen receptor beta on mouse gonadotropin releasing hormone (GnRH) promoter activity. Endocrinology 147: 1924.
Chung WCJ, De Vries GJ, Swaab DF (2002) Sexual differentiation in the bed nucleus of the stria terminalis of the human extends into adulthood. J Neurosci 22: 1027.
Chung WCJ, Swaab DF, De Vries GJ (2000) Apoptosis during postnatal sexual differentiation of the bed nucleus of the stria terminalis in the rat brain. J Neurobiology 43: 234.
- Development neuroendocrinology
- Brain sexual differentiation
- Brain Morphogenesis, proliferation and cell survival
The Society for Neuroscience (www.sfn.org)
The Endocrine Society (www.endo-society.org)
OFFICEDepartment of Biological Sciences
OFFICE HOURSBy appointment.
CONTACT INFOPhone: 330-672-3641
COURSES TEACHINGFall 2013
- BSCI 70196 - 003 Individual Investigation
- BMS 80299 - 001 Dissertation Ii
- BSCI 40195 - 017 St : Advanced Human Psysiology
- BSCI 50195 - 018 St : Advanced Human Physiology
- BSCI 70195 - 018 St : Advanced Human Physiology
- BMS 80299 - 001 Dissertation Ii
- BMS 80199 - 004 Dissertation I