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Pain Signaling

Derek Damron

I have spent the last 17 years investigating the cellular and molecular mechanisms by which general anesthetic agents interact with and activate PKC isoforms in cardiac muscle cells to alter Ca2+ signaling and inotropic signal transduction pathways important for the regulation and modulation of myocardial contractility.  Over the past 4 years, I have extended my studies of anesthetic actions on cardiomyocyte Ca2+ and contractility, to anesthetic interactions with the TRP receptor cation channel family in dorsal root ganglion sensory neurons and signaling pathways impor