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Zhiqiang Wang

Associate Professor

Ph.D., Fudan University, P.R. China
Postdoctoral Fellow, Cleveland Clinic Foundation

Our research interests in a broad sense are to understand the biological functions of certain proteins from their structural point of views. Particularly, we focus on structure-function relationships of metalloenzymes, as well as protein-protein interaction and protein-ligand interactions that are related to signal transductions in cells. Our long-term goal is to translate these basic research studies into the discovery of new drugs and therapeutic methods to treat human diseases.

Our research interests are in the following areas:

  1. Regulation of Nitric Oxide Synthesis in Bacterial Nitric Oxide Synthase (NOS)
  2. Receptor and Protein Interactions in NO Signaling
  3. Structure-function Studies of Heme O2 and NO Sensors
  4. Mechanism of NOS-related Endothelial Dysfunction
Scholarly, Creative & Professional Activities
  1. Tejero, J., Biswas, A., Haque, M.M., Wang, Z.-Q., Hemann, C., Varnado, C.L., Novince, Z., Hille, R., Goodwin. D.C., Stuehr, D.J. “Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.” Biochem. J. 433, 163-74, 2010.
  2. Wang, Z.-Q., Wei, C.-C., and Stuehr, D. J. “How Does A Valine Residue That Modulates Heme-NO Binding Kinetics in Inducible NO Synthase Regulate Enzyme Catalysis” J Inorg. Biochem. 104, 349-56, 2009. 
  3. Wei, C.-C., Wang, Z.-Q., Tejero J, Yang YP, Hemann C, Hille R and Stuehr D. J. “Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase.” J. Biol. Chem., 283, 11734-42, 2008. 
  4. Wang, Z.-Q., Lawson R. J., Madhavan, B. R., Wei, C.-C., Crane, B. R., Munro, A.W., and Stuehr, D. J. “Bacterial Flavodoxin Support Nitric Oxide Production by Bacillus Subtilis Nitric-Oxide Synthase.” J. Biol. Chem., 282, 2196-202, 2007. 
  5. Wang, Z.-Q., Wei, C.-C., Santolini, J., Koustubh, P., Wang, Q. and Stuehr, D. J. “A Tryptophan That Modulates Tetrahydrobiopterin-Dependent Electron Transfer in Nitric Oxide Synthase Regulates Enzyme Catalysis by Additional Mechanisms.” Biochemistry, 44, 4676-90, 2005.
  6. Wang, Z.-Q., Wei, C.-C., Sharma, M., Pant, K., Crane, B. R., and Stuehr, D. J. “A Conserved Val to Ile Switch Near the Heme Pocket of Animal and Bacterial Nitric-Oxide Synthases Helps Determine Their Distinct Catalytic Profiles. J. Biol. Chem., 279, 19018-25, 2004.
  7. Wang, Z.-Q., and Stuehr D. J. “Calcium Signaling: NO Synthase”, Encyclopedia of Biological Chemistry, Edited by William J Lennarz, Deniel M lane, Academic Press, 256-260, Sep 2004.
  8. Wei, C.-C., Wang, Z.-Q., Arvai A. S., Hemann, C., Hille, R., Getzoff E. D., and Stuehr, D. J. “Structure of Tetrahydrobiopterin Tunes Its Electron Transfer to the Heme-dioxy Intermediate in Nitric oxide synthase.” Biochemistry, 42, 1969-77, 2003. 
  9. Cao, C.-Y., Zhang, Q., Wang, Z.-Q., Wang, Y.-H., Wu, H.-M., and Huang, Z.-X. “1H-NMR Studies of the Effect in Heme of Cytochrome b5 Caused by Valine45 Site-directed Mutation.” Biochemie, 85, 1007-1016, 2003.
  10. Wang, Z.-Q., Wei, C.-C., and Stuehr, D.J. "A Conserved Tryptophan 457 Modulates the Kinetics and Extent of N-hydroxy-L-Arginine Oxidation by Inducible Nitric Oxide Synthase” J. Biol. Chem., 277, 12830, 2002.
  11. Wang, Z.-Q., Wei, C.-C., Ghosh S, Meade, A. L., Hemann, C., Hille, R., and Stuehr D. J. "A Conserved Trytophan In Nitric Oxide Synthesis Regulates Heme-dioxy Reduction by Tetrahydrobiopterin" Biochemistry, 40(43), 12819-25, 2001.
  12. Wang, Z.-Q., Wang Y.-H., Wang W.-H., Xue, L.-L., Wu, X.-Z., Xie, Y., and Huang Z.-X., "The Effect of Mutation at Valine-45 on the Stability and Redox Potentials of Trypsin-cleaved Cytochrome b5", Biophysical Chemistry, 83(1), 3-17, 2000.
  13. Wang, Z.-Q., Wang Y.-H., Qian, W., Wang H.-H., Chunyu, L.-J., Xie, Y., and Huang Z.-X., "Methanol-induced Unfolding and Refolding of Cytochrome b5 and Its P40V Mutant Monitored by UV-visible, CD and Fluorescence Spectra", J. Protein Chem., 18(5), 547-55, 1999.
  14. Zhu B., Wang Z.-Q., Li, X.-M., Zhao D.-Q., and Ni, J.-Z., “Lanthanide Metal Complexes for the Hydrolysis of Ribonucleoside 3’,5’-cyclic Phosphate and Deoxyribonucleoside 3’, 5’-cyclic Phosphate”, Journal of Molecular Catalysis A-Chemical, 118(1). L5-L7, 1997. 
  15. Wang, Z.-Q., Zhang S.-G. Liu, Q.-M., and Ni, J.-Z., "Studies on The Action of Rare Earth with Bovine Serum Albumin in Multimolecular System", Journal of Rare Earth (Special Issue), 573, 1995.
Zhiqiang Wang
OFFICE
Department of Chemistry
CONTACT INFO
Phone: 330-339-3391
zwang3@kent.edu