Gadolinium Containing Ion-Exchanging Lattices of Nanoparticles for Non-Toxic MRI Contrast Agents Having High Relaxivity
Abstract: This technology relates to the preparation of a new class of materials and their use as MRI contrast agents. We discovered that doping of Gadolinium (III) ions into a particular ion exchanger lattice can simultaneously increase relaxivity and decrease dissociation of gadolinium (III) ions. This invention describes a new design paradigm for constructing novel gadolinium-doped nanoparticles with high longitudinal relaxivity. The particles of such materials range from 10 to 100 nm. They can be employed as highly effective T1-weighted MRI contrast agents in clinical diagnosis and biomedical research, particularly suited for applications using high magnetic field scanners. The nanoparticles are very stable against agglomeration and leaching of free gadolinium (III) ions at pH 6-7.
· As MRI contrast agents for special applications requiring great sensitivity
Advantages: Due to the presence of gadolinium, the MRI contrast agents described in this invention may not be most suited for routine diagnostic applications using modest magnetic field strength. Note: For those applications, agents described in another Kent State University invention (see KSU.343) may be a better choice. However, because of the remarkably high relaxivity in this invention, this technology may prove to be indispensable for certain special applications where sensitivity is a critical issue. The remarkably high relaxivity of the current agents can allow the concentration to be reduced by at least an order of magnitude, thus minimizing the risk of exposing the patient to gadolinium. These nanoparticles show promise of extremely high in vivo stability and therefore perhaps a solution at last to solve the difficult gadolinium toxicity problem now recognized in MRI contrast agent use.
Inventors: Dr. Songping Huang, Dr. Yongxiu Li, Mohammadreza Shokouhimehr
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