Method of Synthesis of the Sodium Salt of N-Acetyl-L-Cysteinylcobalamin

 KSU.300

Abstract:Vitamin B12 dysfunction is associated with a wide variety of oxidative-stress related diseases.  Thiolatocobalamins such as N-acetylcysteinylcobalamin may protect against oxidative stress much better than currently available forms of vitamin B12.  A simple and convenient method for the synthesis of the novel vitamin B12-based therapeutic N-acetylcysteinylcobalamin has been developed.

Applications:  High homocysteine levels are associated with an increased risk of cardiovascular, peripheral vascular and cerebrovascular diseases.  Furthermore, moderately raised serum homocysteine levels are more prevalent in patients suffering from neurological diseases such as Alzheimer's disease, and appear to predict cognitive decline.

Advantages:  Promising preliminary data in cell models has been obtained in a collaborator's laboratory (see KSU.301) which shows that N-acetylcysteinylcobalamin in combination with folate effectively protects cells against homocysteine and hydrogen peroxide-induced oxidative damage much better than the currently available pharmaceutical forms of vitamin B12.

Inventors:  Nicola E. Brasch, Edward Suarez-Moreira

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Suguna Rachakonda

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