Nanoparticles Based on Gadolinium Coordination Polymers as Highly Sensitive T1 MRI Contrast Agents (Joint technology with CWRU)
An important new application of MRI is as a cellular and molecular probe for early diagnosis of many diseases. For such purpose there is an even greater need for a new sensitive T1 weighted (positive contrast) imaging agent to be made available for disease-related biomarkers and/or the alterations in disease-related gene expressions using MRI modalities. This invention relates to a new class of nanoparticles-based T1-weighted MRI contrast agents with extremely high sensitivity and a low R2-R1 ratio, which make them particularly suitable for cellular and molecular imaging of disease-related biomarkers and the alterations in disease-related gene expressions using MRI modalities.
For magnetic resonance imaging (MRI) contrast agents - for noninvasive biomedical diagnosis of many diseases.
- High relaxivity (sensitivity) for positive contrast imaging
- Reliable preparation
Inventors: Dr. Songping D. Huang and Dr.Yongxiu Li (Kent State University); and Dr. James P. Basilion, Dr. Jihua Hao, and Dr. Chris Flask (Case Western Reserve University)
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