Min-Ho Kim

Research Interests

The major focus of my research interest is to develop therapeutics to promote the resolution of non-healing chronic wounds based on precise understanding of inflammatory response to tissue injury and infection.Many non-healing chronic wounds have been associated with chronic inflammation. A more detailed understanding of mechanisms controlling the inflammatory response and how inflammation directs the outcome of the healing process will provide therapeutics for tissue repair in chronic inflammatory diseases. The long-term goal of my research is to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating macrophages and tissue repair process, and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control of inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, tissue engineering, and nano-bioengineering.

Recent Publications     

• Sung B, Kim D, Vigolo D, Kim MH. Combined effect of matrix topography and stiffness on neutrophil shape and motility. Advanced Biology, In press, 2022
• Pant BD, Benin BM, Abeydeera N, Kim MH, Huang S. Bi₂O₃ nanoparticles exhibit potent broad-spectrum antimicrobial activity and the ability to overcome Ag-, ciprofloxacin- and meropenem-resistance in P. aeruginosa: the next silver bullet of metal antimicrobials? Biomaterials Science, 10:1523-1531, 2022
• Abeydeera N, Yu B, Bishnu P, Kim MH, Huang S. Harnessing the Toxicity of Dysregulated Iron Uptake for Killing Staphylococcus aureus: Reality or Mirage?. Biomaterials Science, 10:474-484, 2022
• Dyne E, Cawood M, Suzelis M, Russell R, Kim MH. Ultrastructural Analysis of the Morphological Phenotypes of Microglia Associated with Neuro-inflammatory Cues. J Comparative Neurology, First published on November 13, 2021, doi: 10.1002/cne.25274
• Dassanayake T, Dassanayake A, Abeydeera N, Bishnu P, Jaroniec M, Kim MH, Huang S. An aluminum lining to the dark cloud of silver resistance: Harnessing the power of potent antimicrobial activity of γ-alumina nanoparticles. Biomaterials Science, 9:7996-8006, 2021
• Wang J, Li J, Benin B, Yu B, Bunge S, Abeydeera N, Huang S, Kim MH. Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus. J Medicinal Chemistry, 64:9381-9388, 2021
• Dyne E, Prakash P, Li J, Yu B, Schmidt T, Huang S, Kim MH. Mild Magnetic Nanoparticle Hyperthermia Promotes the Disaggregation and Microglia-mediated Clearance of Beta-Amyloid Plaques. Nanomedicine: Nanotechnology, Biology, and Medicine, 34:102397, 2021. doi.org/10.1016/j.nano.2021.102397
• Sung B, Kim MH, and Abelmann L. Magnetic Microgels and Nanogels: Physical Mechanisms and Biomedical Applications. Bioengineering and Translational Medicine, 6:e10190, 2021
• Raouf I, Lee J, Kim H, and Kim MH. Parametric investigations of magnetic nanoparticle hyperthermia in ferrofluid using finite element analysis. International Journal of Thermal Sciences, 159: 106604, 2021 
• Garcia G, Kim MH, Morikis V, Simon SI. Neutrophil inflammatory response is downregulated by uptake of superparamagnetic iron oxide nanoparticle therapeutics. Frontiers in Immunology, 11:571489, 2020
• Song R, Yu B, Friedrich D, Li J, Shen H, Krautscheid H, Huang S, and Kim MH. Napthoquinone-derivative as a synthetic compound to overcome the antibiotic resistance of methicillin-resistant S. aureus. Communications Biology, 3:529, 2020 [Behind the paper]
• Turiv T, Krieger J, Babakhanova G, Yu H, Sergij V, Wei Q, Kim MH, and Lavrentovich O. Topology control of human fibroblast cells monolayer by liquid crystal elstomer. Science Advances, 6:eaaz6485, 2020
• Raouf I, Khalid S, Khan A, Lee J, Kim H, and Kim MH. A review on numerical modeling of magnetic nanoparticle hyperthermia: Progress and challenges. Journal of Thermal Biology, 91:102644, 2020
• Boler D, Kim MH, Krieger J, Martin J, Milkowski A, Mozdziak P, Sylvester P., Producing food products from cultured animal tissue. CAST Commentary, QTA2020-1, April 2020
• Babakhanova G, Krieger J, Li B, Turiv T, Kim MH, and Lavrentovich O. Cell alignment by smectic liquid crystal elastomer coatings with nanogrooves. Journal of Biomedical Materials Research Part A, 108:1223-1230, 2020
• Yu B., Wang Z., Almutairi L., Huang S.,and Kim MH. Harnessing iron oxide nanoparticles towards the improved bactericidal activity of macrophages against Staphylococcus aureus. Nanomedicine: Nanotechnology, Biology, and Medicine, 24:102158, 2020
• Almutairi L, Yu B, Filka M, Nayfach J, and Kim MH. Mild magnetic nanoparticle hyperthermia synergistically enhances the susceptibility of Staphylococcus aureus biofilm to antibiotics.  International Journal of Hyperthermia, 37:66-75, 2020
• Alboslemy T, Yu B, Rogers T, and Kim MH. Staphylococcus aureus biofilm-conditioned medium impairs macrophage-mediated antibiofilm immune response by upregulating KLF2 expression. Infection and Immunity, 87:e00643-18, DOI:10.1128/IAI.00643-18, 2019
• Sung B, Krieger J, Yu B, and Kim MH. Colloidal gelatin microgels with tunable elasticity support the viability and differentiation of mesenchymal stem cells under pro-inflammatory conditions. Journal of Biomedical Materials Research Part A, 106:2753-2761, 2018
• Wang Z, Yu B, Alamri H, Yarabarla S, Kim MH, Huang S*. KCa(H2O)2[FeIII(CN)6].H2O nanoparticles as a novel antimicrobial agent for Staphylococcus aureus. Angewandte Chemie, 57:2214-2218, 2018
• Sung B and Kim MH. Liquid-crystalline nanoarchitectures for tissue engineering. Beilstein Journal of Nanotechnology. 9:205-215, 2018
• Yu B, Alboslemy T, Safadi F, Kim MH. Glycoprotein non-melanoma clone B regulates the crosstalk between macrophages and mesenchymal stem cells towards wound repair. Journal of Investigative Dermatology, 138:219-217, 2018

Click here for complete list of published works

Courses Teaching

Spring 2022

• BSCI 4/5/70158  Molecular Biology
• BSCI 40600 Writing In Biological Sciences

Fall 2022

• BSCI 4/5/70463 - Medical Biotechnology
• BSCI 40600 - Writing In Biological Sciences