Professor Clewell joined the Department of English in 2000 and has since published essays on modernism, psychoanalysis, and film in journals including Modern Fiction Studies, Literature/Film Quarterly, Angelaki, College Literature, and The Journal of the American Psychoanalytic Association. Her essay on Freud and mourning received the 2001 CORST Prize awarded by the American Psychoanalytic Association.
Regenerative medicine, mitochondrial dysfunction and epigenetic mechanisms in multiple sclerosis.
Neurodegeneration, vascular smooth muscle cell function, biochemistry of multiple sclerosis.
Protein kinase C in stroke-reperfusion injuries.
The McDonough lab is focused on identifying neuroprotective therapies for multiple sclerosis (MS). This disease is the leading cause of neurological disability in young adults.
Ongoing projects in the lab include investigating the role of changes in methionine metabolism and histone methylation in MS pathology. We have found that decreased levels of methyl donors S-adenosylmethionine and betaine are linked to mitochondrial defects in MS.
