Skip to main content

A-Z Index

  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • R
  • S
  • T
  • U
  • V
  • W

Flashes Safe Seven utility icon

  • Apply
  • Visit
  • Give Now
  • Flashes Safe Seven
  • FlashLine Login
  • Calendars
  • Phone Directory
    • Faculty & Staff Phone Directory
    • Emeriti or Retiree
    • All Departments
  • Maps & Directions
  • Search
Kent State University Home
Brain Health Research Institute
Institutes & Initiatives
Menu
  • About
    Close About Overview
    • Mission
    • People
    • Participants/Partners
    • Research Institutes & Initiatives
    • Directions
  • Research
    Close Research Overview
    • Research Theme Areas
    • Collaboratories
  • News
  • Academic Programs
  • Seminars
    Close Seminars Overview
    • BHRI Seminars
    • Co-hosted Seminars
  • Symposium
    Close Symposium Overview
    • 2020 Neuroscience Symposium
    • 2019 Neuroscience Symposium
    • 2018 Neuroscience Symposium
    • 2017 Neuroscience Symposium
    • 2016 Neuroscience Symposium
  • BHRI Fellows
  • Flashes Safe Seven
  • FlashLine Login
  • Calendars
  • Phone Directory
    • Faculty & Staff Phone Directory
    • Emeriti or Retiree
    • All Departments
  • Maps & Directions
  • Search
  • Apply
  • Visit
  • Give Now
Live Chat
Jennifer McDonough

Jennifer McDonough

Assistant Professor - Biological Sciences
Contact Information
Email:
jmcdonou [at] kent.edu
Phone:
330-672-2388
Personal Website:
McDonough Lab

Biography

The McDonough lab is focused on identifying neuroprotective therapies for multiple sclerosis (MS).  Ongoing projects in the lab include investigating the role of changes in methionine metabolism and histone methylation in MS pathology.  We have found that decreased levels of methyl donors S-adenosylmethionine and betaine are linked to mitochondrial defects in MS. 

We also have exciting new data demonstrating that hemoglobin is expressed in both the cytoplasm and in the nucleus of pyramidal neurons in the human cortex.  We have identified hemoglobin interacting proteins in neurons by mass spectrometry and found that it interacts with mitochondria and with nuclear proteins including histones and a histone demethylase.  Our data suggest that hemoglobin signals between mitochondria and the nucleus to regulate neuronal energetics.  We have found that the subcellular localization of hemoglobin is dysregulated in MS and may contribute to mitochondrial impairment in this disease. 

Recent Publications: 

Singhal N K , Li S, Arning E, Alkhayer K, Clements R, Sarcyk Z, Dassanayake R S,  Brasch N E, Freeman E J,  Bottiglieri T,  McDonough J.  (2015)  Changes in Methionine Metabolism and Histone H3 Trimethylation are Linked to Mitochondrial Defects in Multiple Sclerosis, J. Neurosci. 35, 15170 –15186.

Li S, Clements R, Sulak M, Gregory R, Freeman E, McDonough J. (2013) Decreased NAA in Gray Matter is Correlated with Decreased Availability of Acetate in White Matter in Postmortem Multiple Sclerosis Cortex.  Neurochem. Res., 38, 2385-2396. 

Broadwater, L., Pandit, A., Clements, R., Azzam, S., Vadnal, J., Sulak, M., Yong, V.W., Freeman, E.,             Gregory, R., McDonough, J.  (2011)  Analysis of the mitochondrial proteome in multiple sclerosis cortex.  Biochim. Biophys. Acta, 1812, 630-641.  

 

Courses Teaching  

 

BSCI 70143  Eukaryotic Cell Biology

Education

Ph.D., Case Western Reserve University

Affiliations

Oak Clinic for MS
Brain Health Research Institute
Institutes & Initiatives

Mailing Address

P.O. Box 5190
Kent, OH 44242-0001


Street Address

800 E. Summit St.
Kent, OH 44242

Street Address

251M Integrated Sciences Building, 1175 Lefton Esplanade, Kent, OH 44242

Mailing Address

800 E. Summit St.
Kent, OH 44242

Contact Us

  • 330-672-3000
  • info@kent.edu

Contact Us

330-672-1855
brainhealth [at] kent.edu
Facebook Facebook
Twitter Twitter

Quick Links

  • Biological Sciences
  • Psychological Sciences
  • School of Biomedical Sciences
  • Kent State Kent Campus - Facebook
  • Kent State Kent Campus - Twitter
  • Kent State Kent Campus - YouTube
  • Kent State Kent Campus - Instagram
  • Kent State Kent Campus - LinkedIn
  • Kent State Kent Campus - Snapchat
  • Kent State Kent Campus - Pinterest
  • ...

Information

  • Accessibility
  • Annual Security Reports
  • Emergency Information
  • For Our Alumni
  • For the Media
  • Health Services
  • Jobs & Employment
  • Privacy Statement
  • HEERF/CARES Act Reporting and Disclosure
  • Website Feedback
Kent State University Home
© 2021 Kent State University All rights reserved.