The major focus of my research interest is to develop therapeutics to promote the resolution of non-healing chronic wounds based on precise understanding of inflammatory response to tissue injury and infection.Many non-healing chronic wounds have been associated with chronic inflammation. A more detailed understanding of mechanisms controlling the inflammatory response and how inflammation directs the outcome of the healing process will provide therapeutics for tissue repair in chronic inflammatory diseases. The long-term goal of my research is to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating macrophages and tissue repair process, and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control of inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, tissue engineering, and nano-bioengineering.
Selected Publications (recent three years)
Song R, Yu B, Friedrich D, Li J, Shen H, Krautscheid H, Huang S, and Kim MH. Napthoquinone-derivative as a synthetic compound to overcome resistance in MRSA. Communications Biology, Accepted 2020