Raghanti Laboratory

How did the human brain evolve? A hallmark of the human condition is a dramatically enlarged brain, and discovering how the human brain differs from those of other species is central to understanding human evolution. Answering such questions is the primary research focus of the Raghanti laboratory. Using a comparative approach with an evolutionary perspective, the lab addresses neuromodulation of cognition, hormonal correlates of nonhuman primate behavior, and neural mechanisms of social attachment.

About the Laboratory

Facilities includes a full wet lab with all necessary equipment for running histological, immunohistochemical, and enzyme-linked immunoassay procedures, and a microscope suite with an Olympus BX51 microscope equipped with MBF Bioscience StereoInvestigator software. This system includes a motorized stage and color digital camera for high-resolution image montage acquisition for brightfield and darkfield photomicrographs.

More Info

Dr. Raghanti's laboratory is funded by the National Science Foundation (NSF BCS-1316829).

 

Publications

* KSU graduate student; ** KSU undergraduate student

1. Charvet, C.J., Stimpson, C.D., Kim, Y.D., Raghanti, M.A., Lewandowski, A.L., Hof, P.R., Gomez-Robles, A., Krienen, F.M., Sherwood, C.C. (in press) Gradients in cytoarchitectural landscapes of the isocortex: diprotodont marsupials in comparison to eutherian mammals. Journal of Comparative Neurology.

2. Fuller, G., Raghanti, M.A., Dennis, P.M., Kuhar, C.W., Willis, M.A., Schook, M.W., Lukas, K.E. (in press) A comparison of nocturnal primate behavior in exhibits illuminated with red and blue light. Applied Animal Behavior Science.

3. Stephenson, A.R.*, Edler, M.E.*, Erwin, J.M., Jacobs, B., Hopkins, W.D., Hof, P.R., Sherwood, C.C., Raghanti, M.A. (2017) Cholinergic innervation of the basal ganglia among human and nonhuman primates. Journal of Comparative Neurology 525, 319-332.

4. Charvet, C.J., Hof, P.R., Raghanti, M.A., Van der Kouwe, A.J., Sherwood, C.C., Takahashi, E. (in press) Combining diffusion MR tractography with stereology highlights increased cross-cortical integration in primates. Journal of Comparative Neurology.

5. Johnson, C.B., Schall, M., Tennison, M.E., Garcia, M.E., Shea-Shumsky, N.B., Raghanti, M.A., Lewandowski, A.L., Bertelsen, M.F., Waller, L.C., Walsh, T., Roberts, J.F., Hof, P.R., Sherwood, C.C., Manger, P.R., Jacobs, B. (2016) Neocortical neuronal morphology in the Siberian tiger (Panthera tigris altaica) and the clouded leopard (Neofelis nebulosa). Journal of Comparative Neurology 524: 3641-3665.

6. Asmus, S.E., Raghanti, M.A., Beyerle, E.R., Fleming, J.C., Hawkins, S.M., McKernan, C.M., Rauh, N. (2016) Tyrosine hydroxylase-producing neurons in the human cerebral cortex do not colocalize with calcium-binding proteins or the serotonin 3A receptor. Journal of Chemical Neuroanatomy 78, 1-9.

7. Ruth, A.A.*, Raghanti, M.A., Meindl, R.S., Lovejoy, C.O. (2016) Locomotor pattern fails to predict foramen magnum angle in rodents, strepsirrhine primates, and marsupials. Journal of Human Evolution 94, 45-52.

8. Jacobs, B., Lee, L., Schall, M., Raghanti, M.A., Lewandowski, A., Kottwitz, J.J., Roberts, J.F., Hof, P.R., Sherwood, C.C. (2016) Neocortical neuronal morphology in the newborn giraffe (Giraffa Camelopardalis tippelskirchi) and newborn African elephant (Loxodonta Africana) Journal of Comparative Neurology 524, 257-287.

9. Raghanti, M.A., Edler, M.E.*, Stephenson, A.R.*, Wilson, L.J.**, Hopkins, W.D., Ely, J.J., Erwin, J.M., Jacobs, B., Hof, P.R., Sherwood, C.C. (2016) Human-specific increase in dopaminergic innervation in a striatal region associated with speech and language: a comparative analysis of the primate basal ganglia. Journal of Comparative Neurology 524, 2117-2129.

10. Reyes, L.D., Stimpson, C.D., Gupta, K., Raghanti, M.A., Hof, P.R., Reep, R.L., Sherwood, C.C. (2015) Neuron types in the presumptive primary somatosensory cortex of the Florida manatee (Trichechus manatus latirostris). Brain Behavior and Evolution 86, 21-231.

11. Phillips, K.A., Stimpson, C.D., Smaers, J.B., Raghanti, M.A., Jacobs, B., Popratiloff, A., Hof, P.R., Sherwood, C.C. (2015) The corpus callosum in primates: Processing speed of axons and the evolution of hemispheric asymmetry. Proceedings of the Royal Society B 282:20151535. http://dx.doi.org/10.1098/rspb.2015.1535.

12. Sensor, J.D., Suydam, R., Liberman, M.C., Lovano, D., Raghanti, M.A., Usip, S., Vinyard, C.J., Thewissen, J.G.M. (2015) The spiral ganglion and Rosenthal’s canal in Beluga whales. Journal of Morphology 276, 1455-1466.

13. Schook, M.W., Wildt, D.E., Raghanti, M.A., Wolfe, B.A., Dennis, P.M. (2015) Increased inflammation and decreased insulin sensitivity indicate metabolic disturbances in zoo-housed managed compared to free-ranging black rhinoceros (Diceros bicornis). General and Comparative Endocrinology 217-218, 10-19.

14. Muntané, G., Horvath, J.E., Hof, P.R., Ely, J.J., Hopkins, W.D., Raghanti, M.A., Lewandowski, A.H., Wray, G.A., Sherwood, C.C. (2015) Analysis of synaptic gene expression in primates reveals changes in glutamate processing. Cerebral Cortex, 25, 1596-1607.

15. Raghanti, M.A., Spurlock, L.B., Treichler, F.R., Weigel, S.E.*, Stimmelmayr, G.R., Butti, C., Thewissen, J.G.M., Hof, P.R. (2015) An analysis of von Economo neurons in the cerebral cortex of cetaceans, artiodactyls, and perissodactyls. Brain Structure and Function 220, 2303-2314.

16. Jacobs, B., Johnson, N., Wahl, D., Schall, M., Maseko, B.C., Lewandowski, A., Raghanti, M.A., Wicinski, B., Butti, C., Hopkins, W.D., Bertelsen, M.F., Walsh, T., Roberts, J.R., Reep, R.L.,  Hof, P.R., Sherwood, C.C., Manger, P.R. (2014) Comparative neuronal morphology of the cerebellar cortex in afrotherians, carnivores, cetartiodactyls, and primates. Frontiers in Neuroanatomy doi. 10.3389/fnana.2014.00024.

17. Duka, T, Anderson, S.M., Collins, Z., Raghanti, M.A., Ely, J.J., Hof, P.R., Wildman, D.E., Goodman, M., Grossman, L.I., Sherwood, C.C. (2014) Synaptosomal lactate dehydrogenase isoenzyme composition is shifted toward aerobic forms in primate brain evolution. Brain Behavior and Evolution 83, 216-230.

18. Less, E.H., Lukas, K.E., Bergl, R., Ball, R., Kuhar, C.W., Lavin, S.R., Raghanti, M.A., Wensvoort, J., Willis, M.A., Dennis, P.M. (2014) Implementing a low-starch biscuit-free diet in zoo gorillas: The impact on health. Zoo Biology 33, 74-80.

19. Less, E.H., Bergl, R., Ball, R., Dennis, P.M., Kuhar, C.W., Lavin, S.R., Raghanti, M.A., Wensvoort, J., Willis, M.A., Lukas, K.A. (2014) Implementing a low-starch biscuit-free diet in zoo gorillas: The impact on behavior. Zoo Biology 33, 63-73.

20. Raghanti, M.A., Edler, M.K.*, Meindl, R.S., Sudduth, J.*, Bohush, T.*, Erwin, J.M., Stimpson, C.D., Hof, P.R., Sherwood, C.C. (2014) Humans and great apes share increased neocortical neuropeptide Y innervation compared to other haplorhine primates. Frontiers in Human Neuroscience doi:10.3389/fnhum.2014.00101.

21. Butti, C., Fordyce, E.R., Raghanti, M.A., Gu, X., Bonar, C.J., Wicinski, B.A., Wong, E.W., Roman, J., Brake, A., Eaves, E. Tang, C.Y., Jacobs, B., Sherwood, C.C., Hof, P.R. (2014) The cerebral cortex of the pygmy hippopotamus, Hexaprotodon liberiensis (Catartiodactyla, Hippopotamidae): MRI, cytoarchitecture, and neuronal morphology. The Anatomical Record 297, 670-700.

22. Barks, S.K., Bauernfeind, A.L., Bonar, C.J., Cranfield, M.R., de Sousa, A.A., Erwin, J.M., Hopkins, W.D., Lewandowski, A.H., Mudakikwa, A., Phillips, K.A., Raghanti, M.A., Stimpson, C.D., Hof, P.R., Zilles, K., Sherwood, C.C. (2014) Variable temporo-insular cortex neuroanatomy in primates suggests a bottleneck effect in eastern gorillas. Journal of Comparative Neurology 522:844-860.

23. Perez, S.E., Raghanti, M.A., Hof, P.R., Kramer, L., Ikonomovic, M.D., Lacor, P.N., Erwin, J.M., Sherwood, C.C., Mufson, E.J. (2013) Alzheimer’s Disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). Journal of Comparative Neurology 521, 4318-4338.

24. Bauernfeind, A.L., de Sousa, A.A., Avasthi, T., Dobson, S.D., Raghanti, M.A., Lewandowski, A.H., Zilles, K., Semendeferi, K., Allman, J.M., Craig, A.D., Hof, P.R., Sherwood, C.C. (2013) A volumetric comparison of the insular cortex and its subregions in primates. Journal of Human Evolution 64, 263-279.

25. Raghanti, M.A., Conley, T.**, Sudduth, J.*, Erwin, J.M., Stimpson, C.D., Hof, P.R., Sherwood, C.C. (2013) Neuropeptide Y-immunoreactive neurons in the cerebral cortex of humans and other haplorhine primates. American Journal of Primatology 75, 415-424.

26. Sayers, K. Raghanti, M.A., Lovejoy, C.O. (2012) Human evolution and the chimpanzee referential doctrine. Annual Review of Anthropology 41, 119-138.

27. Muehlenbein, M.P., Ancrenaz, M., Sakong, R., Ambu, L., Prall, S., Fuller, G., Raghanti, M.A. (2012) Ape conservation physiology: Fecal glucocorticoid responses in wild Pongo pygmaeus morio following human visitation. PLoS One doi:10.1371/journal.pone.0033357.

28. Sherwood, C.C., Bauernfeind, A.L., Bianchi, S., Raghanti, M.A., Hof, P.R. (2012) Human brain evolution writ large and small. Progress in Brain Research 195, 237-254.

29. Eaton, J.L., Roache, L., Nguyen, K.N., Cushing, B.S., Troyer, E., Papademetriou, E., Raghanti, M.A. (2012) Organizational effects of oxytocin on serotonin innervation. Developmental Psychobiology 54, 92-97.

30. Raghanti, M.A., Simic, G., Watson, S.**, Stimpson, C.D., Hof, P.R., Sherwood, C.C. (2011) Comparative analysis of the nucleus basalis of Meynert among primates. Neuroscience 184, 1-15.

31. Butti, C., Raghanti, M.A., Sherwood, C.C., Hof, P.R. (2011) The neocortex of cetaceans: cytoarchitecture and comparison with other aquatic and terrestrial species. Annals of the New York Academy of Sciences 1225, 47-58.

32. Raghanti, M.A., Spocter, M.A., Butti, C., Hof, P.R., Sherwood, C.C. (2010) A comparative perspective on minicolumns and inhibitory GABAergic interneurons in the neocortex.  Frontiers in Neuroanatomy doi:10.3389/neuro.05.035.2010.

33. Treichler, F.R., Raghanti, M.A. (2010) Monkeys Combining Serial Lists: Test Cues and Linking.  Animal Cognition 13, 121-131.

34. Sherwood, C.C., Raghanti, M.A., Stimpson, C.D., Uddin, M., Spocter, M.A., Bonar, C.J.,  Phillips, K.A., Preuss, T.M., Erwin, J.M., Hof, P.R. (2010) Inhibitory interneurons of the human frontal cortex: evolution of the phenotype and related genes.  Proceedings of the Royal Society B: Biological Sciences 299, 1011-1020.

35. Raghanti, M.A., Spocter, M.A., Stimpson, C.D., Erwin, J.M., Bonar, C.J., Allman, J.M., Hof, P.R., Sherwood, C.C. (2009) Species-specific distributions of tyrosine hydroxylase-immunoreactive neurons within the prefrontal cortex of anthropoid primates. Neuroscience 158, 1551-1559. 

36. Raghanti, M.A., Stimpson, C.D., Marcinkiewicz, J.L., Erwin, J.M., Hof, P.R., Sherwood, C.C. (2008) Cortical dopaminergic innervation among humans, chimpanzees, and macaque monkeys: A comparative study. Neuroscience 155, 203-220. 

37. Raghanti, M.A., Stimpson, C.D., Marcinkiewicz, J.L., Erwin, J.M., Hof, P.R., Sherwood, C.C. (2008) Cholinergic innervation of the frontal cortex:  Differences among humans, chimpanzees, and macaques. Journal of Comparative Neurology 506, 409-424. 

38. Raghanti, M.A., Stimpson, C.D., Marcinkiewicz, J.L., Erwin, J.M., Hof, P.R., Sherwood, C.C. (2008) Differences in cortical serotonergic innervation among humans, chimpanzees, and macaque monkeys: A comparative study. Cerebral Cortex 18, 584-597. 

39. Treichler, F.R., Raghanti, M.A., Van Tilburg, D.N. (2007) Serial list linking by macaque monkeys (Macaca mulatta): List property limitations. Journal of Comparative Psychology 121, 250-259. 

40. Sherwood, C.C., Raghanti, M.A., Stimpson, C.D., Bonar, C.J., de Sousa, A.J., Preuss, T.M., and Hof, P.R. (2007) Scaling of inhibitory interneurons in areas V1 and V2 of anthropoid primates as revealed by calcium-binding protein immunohistochemistry.  Brain, Behavior and Evolution 69, 176-195.

41. Sherwood, C.C., Stimpson, C.D., Raghanti, M.A., Wildman, D.E., Uddin, M., Grossman, L.I., Goodman, M., Redmond, J.C., Bonar, C.J., Erwin, J.M., Hof, P.R. (2006) Evolution of increased glial cell density in the human frontal cortex.  Proceedings of the National Academy of Sciences 103, 13606-13611. 

42. Ulyan, M.J., Burrows, A.E., Buzzell, C.A., Raghanti, M.A., Marcinkiewicz, J.L., Phillips, K.A. (2006) The effects of predictable and unpredictable feeding schedules on the behavior and physiology of captive brown capuchins (Cebus apella).  Applied Animal Behavior Science 101, 154-160. 

43. Sherwood, C.C., Raghanti, M.A., Wenstrup, J.J. (2005) Is humanlike cytoarchitectural asymmetry present in another species with social vocalization?  A stereologic analysis of mustached bat auditory cortex.  Brain Research 1045, 164-174. 

44. Treichler, F.R., Raghanti, M.A., Van Tilburg, D.N. (2003) Linking of serially ordered lists by macaque monkeys:  List position influences.  Journal of Experimental Psychology:  Animal Behavior Processes 29, 211-221.

45. Norconk, M.A., Raghanti, M.A., Martin, S.K., Grafton, B.W., Gregory, L.T., De Dijn, B. (2003) Primates of Brownsberg Natuurpark, Suriname, with particular attention to the Pitheciins.  Neotropical Primates 11, 94-100.  

BOOK CHAPTERS

1. Raghanti, M.A., Munger, E.A.*, Wicinski, B., Butti, C., Hof, P.R. (2017) Comparative structure of the cerebral cortex in large mammals. In Evolution of Nervous Systems 2e, Volume 2, pp 267-289. Kaas, J.H., Editor. Elsevier.

2. Sherwood, C.C., Bauernfeind, A.L., Verendeev, A., Raghanti, M.A., Hof, P.R. (2017) Evolutionary specializations of human brain microstructure. In Evolution of Nervous Systems 2e. Kaas, J.H., Editor. Volume 4, pp 121-139. Elsevier.

3. Spocter, M.A., Raghanti, M.A., Sherwood, C.C. (2015) The minicolumn in comparative context: variation and evolution in the cortical column. In Recent Advances on the Modular Organization of the Cerebral Cortex, pp 63-80. Casanova, M. and Opris, I., Editors. Springer Publishing.

4. Raghanti, M.A., Spurlock, L.B., Uppal, N., Sherwood, C.C., Butti, C., Hof, P.R. (2015) Von Economo neurons. In Brain Mapping: An Encyclopedic Reference, vol. 2, pp 81-91. Academic Press: Elsevier.

5. Raghanti, M.A., Hof, P.R., Sherwood, C.C. (2010) The evolution of cortical neurotransmitter systems among primates and their relevance to cognition, pp 195-212. In The Human Brain Evolving: Paleoneurological studies in honor of Ralph L. Holloway. Broadfield, D., Yuan, M., Schick, K., Toth, N. Editors.

COMMENTARY/EDITORIAL

Raghanti, M.A., Todd, N., Hof, P.R. (2015) Probing the Proboscidea: Lessons from the past. Journal of Comparative Neurology 523, 2321-2325.