Lee Gilman
Biography
Graduate Areas:
Does Dr. Gilman plan to recruit a doctoral student for the next incoming class?
Research Interests:
Research in the Gilman lab is focused on bridging gaps in knowledge about how consuming unhealthy diets, or experiencing other forms of environmental stress, feed forward to promote maladaptive behavioral changes. Such behavioral shifts include persistent consumption of unhealthy diet, inappropriate responses to stressors, or both, frequently culminating in psychiatric diseases (e.g., depression, anxiety) that are comorbid with metabolic or cardiovascular diseases. Specifically, we are investigating how diet- and stress-related neuroactive hormones (e.g., insulin, corticosterone) modulate dopaminergic signaling to initiate and perpetuate this feed-forward pathophysiology that can dramatically impact behavior.
Lab Site: https://tleegilman.wixsite.com/gilmanlab
Courses Frequently Taught:
- Biopsychology
Publications:
- Gilman TL*, George CM, Andrade M, Mitchell NC, Toney GM, Daws LC (2019) High salt intake lowers behavioral inhibition. Front Behav Neurosci 13:271 PMID: 31920580 *corresponding author
- Gilman TL, Owens WA, George CM, Metzel L, Vitela M, Ferreira L, Bowman MA, Gould GG, Toney GM, Daws LC (2019) Age- and sex-specific plasticity in dopamine transporter function revealed by food restriction and exercise in a rat activity-based anorexia paradigm. J Pharmacol Exp Ther 371(2):268-277 PMID: 31481515
- Gilman TL*, Mitchell NC*, Daws LC, Toney GM (2019) Neuroinflammation contributes to high salt intake-augmented neuronal activation and active coping responses to acute stress. Int J Neuropsychopharmacol 22(2):137-142 PMID: 30535261 *contributed equally
- Gilman TL, Dutta S, Adkins JM, Cecil CA, Jasnow AM (2018) *Basolateral amygdala Thy1-expressing neurons facilitate the inhibition of contextual fear during consolidation, reconsolidation, and extinction. Neurobiol Learn Mem 155:498-507 PMID: 30287384 *issue cover
- Gilman TL*, George CM, Vitela M, Herrera-Rosales M, Basiouny MS, Koek W, Daws LC (2018) Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety-like and coping behaviours. Eur J Neurosci 48(1):1706-1716 PMID: 29797618 *corresponding author
- Nylocks KM, Gilman TL, Latsko MS, Jasnow AM, Coifman KG (2018) Increased para-sympathetic activity and ability to generate positive emotion: The influence of the BDNF Val66Met polymorphism on emotion flexibility. Motiv Emot 42(4):586-601 doi: 10.1007/s11031-018-9679-1
- Mitchell NC, Gilman TL, Daws LC, Toney GM (2018) High salt intake enhances swim-stress induced PVN vasopressin cell activation and active stress coping. Psychoneuroendocrinology 93:29-38 PMID: 29684712
- Gilman TL, Shaheen R, Nylocks KM, Halachoff D, Chapman J, Flynn JJ, Matt LM, Coifman KG (2017) A film set for the elicitation of emotion in research: A comprehensive catalog derived from four decades of investigation. Behav Res Methods 49(6):2061-2082 PMID: 28078572
- Lynch JF, Winiecki P, Gilman TL, Adkins JM, Jasnow AM (2017) Hippocampal GABAB(1a) receptors constrain generalized contextual fear. Neuropsychopharmacology 42(4):914-924 PMID: 27834391
- Latsko MS, Gilman TL, Matt LM, Nylocks KM, Coifman KG, Jasnow AM (2016) A novel interaction between tryptophan hydroxylase 2 (TPH2) gene polymorphism (rs4570625) and BDNF Val66Met and inhibition of negative emotion; evidence suggestive of two “at-risk” groups. PLoS ONE 11(10):e0162585 PMID: 27695066