Neurological Research Helps Develop Potential Autism Pharmaceuticals

Photo by Anna Shvets

Autism spectrum disorder (ASD) is a group of neurodevelopmental disabilities characterized by social communication deficits and stereotypic behaviors. Currently, little is known about the cellular and molecular mechanisms of ASD, but the research of Department of Biological Sciences Associate Professor Woo-Yang Kim, Ph.D., might lead to a change. 

Woo-Yang Kim

As opposed to other diseases, infections or environmental exposures, there is no known factor that causes ASD. Kim’s research started with mice, targeting to identify causal factors and related brain mechanisms.

To make a working nervous system, two forces are necessary: excitation and inhibition. Excitatory signaling from one cell to another makes the latter cell more likely to fire. Inhibitory signaling makes the latter cell less likely to fire.

“Decreased inhibitory activity was found in the mouse model that shifted the balance between excitation and inhibition toward excitation,” Kim said. “One way to rescue this imbalance is to increase the inhibitory tone in the brain.”

Kim’s research with mice has led to identifying and further testing for a potential treatment option for ASD. 

A drug (Clonazepam) was developed based on the brain analysis of the mouse subject. This drug acts by increasing the level of inhibitory activity in the brain. Kim’s research found that clonazepam reverses ASD symptoms in the mouse model.

These results are now being tested in human clinical trials with the help of collaborators outside Kent State. 

“We’re hoping they’ll find the same results we did in our preclinical trials,” he said. 

Current graduate students have also been working on this project with the help of select undergraduate students.  

Kim says that current and future studies will focus on molecular mechanisms, develop potential treatment tools for autism related developmental conditions and develop a biomarker for diagnosis and clinical endpoint assessment.

Biomarker development is particularly important for ASD research. 

“One of the biggest challenges in the autism research field is a lack of a reliable biomarker for the disorder,” he said. “That creates difficulties in assessing patients when we develop drugs.”

Read more about Kim and his research.

Read more about the Department of Biological Sciences.

POSTED: Tuesday, May 10, 2022 - 10:32am
UPDATED: Friday, May 13, 2022 - 12:44pm
WRITTEN BY:
Ian Jameson